Prospective, open-label, randomized, phase III study of two dose-dense regimens MVAC versus gemcitabine/ cisplatin in patients with inoperable, metastatic or relapsed urothelial cancer: a Hellenic Cooperative Oncology Group study
نویسندگان
چکیده
Prospective, open-label, randomized, phase III study of two dose-dense regimens MVAC versus gemcitabine/ cisplatin in patients with inoperable, metastatic or relapsed urothelial cancer: a Hellenic Cooperative Oncology Group study (HE 16/03) A. Bamias1, U. Dafni2, A. Karadimou1, E. Timotheadou3, G. Aravantinos4, A. Psyrri5, I. Xanthakis2, M. Tsiatas1, V. Koutoulidis6, C. Constantinidis7, C. Hatzimouratidis8, E. Samantas4, A. Visvikis4, M. Chrisophos9, K. Stravodimos7, C. Deliveliotis9, A. Eleftheraki10, D. Pectasides11, G. Fountzilas3 & M. A. Dimopoulos1 Department of Clinical Therapeutics, Alexandra Hospital, Athens University Medical School, Athens; Laboratory of Biostatistics, University of Athens School of Nursing, Athens; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki; 3rd Department of Medical Oncology, Agii Anargiri Cancer Hospital; 2nd Propaedeutic Department of Internal Medicine, Oncology Section, University General Hospital Attikon; 1st Radiology Department, Areteion Hospital, Athens University Medical School; Department of Urology, Laikon Hospital, Athens University Medical School, Athens; Department of Urology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki; Department of Urology, Sismanoglion Hospital, Athens University Medical School, Athens; Section of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, Athens; Second Department of Internal Medicine, Oncology Section, Hippokration Hospital, Athens, Greece
منابع مشابه
Efficacy of methotrexate/vinblastine/doxorubicin cisplatin combination in gemcitabine-pretreated patients with advanced urothelial cancer: a retrospective analysis
OBJECTIVE Second-line treatment options in advanced urothelial cancer are limited. We investigated the efficacy of a methotrexate/vinblastine/doxorubicin/cisplatin (MVAC) combination after failure of gemcitabine/platinum chemotherapy. PATIENTS AND METHODS Twenty-five patients with advanced urothelial cancer, who received second-line MVAC after first-line gemcitabine/cisplatin (n = 9) or gemci...
متن کاملSystemic chemotherapy in inoperable or metastatic bladder cancer.
Urothelial cancer is a common malignancy. The management of patients with recurrent disease after cystectomy or initially metastatic or unresectable disease represents a therapeutic challenge. Systemic chemotherapy prolongs survival but long-term survival remains infrequent. During recent years there has been improvement due to the use of novel chemotherapeutic agents, mainly gemcitabine and th...
متن کاملTailored Selection of First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma of Bladder
PURPOSE Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS Patients who were initially diagnosed to have mUCB and received MVAC or GC as metastatic first-line chem...
متن کاملCritical evaluation of vinflunine in the treatment of refractory metastatic urothelial carcinoma
Urothelial carcinoma (UC) accounts for 5% to 10% of malignancies in men in Europe and the United States. For locally advanced or metastatic disease, there are two standard firstline chemotherapy regimens: MVAC (methotrexate, vinblastine, doxorubicin, cisplatin) and gemcitabine/cisplatin. For refractory disease, there is currently no standard treatment. Vinflunine, a second-generation Vinca alka...
متن کاملComparative study between two treatment regimens of Cisplatin-5-Fluorouracil and Gemcitabine-Cisplatin in gallbladder cancer patients
The research study was designed to compare the safety and efficacy of the regimen of 5-flurouracil with cisplatin of investigational arm with the reference regimen of gemcitabine with cisplatin for the treatment of gallbladder cancer. A total of 60 patients were enrolled in the study. Out of 30 patients enrolled in arm-A (Gemcitabine with Cisplatin) and 30 patients enrolled in arm-B (5-Fluroura...
متن کامل